Doomed to repeat history?

There’s an article on Nature’s site that announces the finding of a gene which, when absent, softens the impact of negative reinforcement. The article goes on to say that those without the gene are constitutionally more intent than others on seeking highs — that is to say, engaging in addictive behaviors.

When reading this, I get another takeaway: that this same “flaw” reduces its carriers’ risk aversion, which is a big boost to successful serial entrepreneurship, the pursuit of applied knowledge, &c.

This leaves another mystery to be solved: why do those same people so often have an aversion trending toward pathology of conceding their mistakes? Is that a consequence of acculturation, or some other genetic flaw?